Endocrine Abstracts

The intrinsic selectivity and flexibility of bioorthogonal click chemistries make them an almost ideal synthetic methodology for the creation of radiolabeled PET imaging agents. One type of bioorthogonal reaction, the inverse electron demand Diels-Alder reaction between tetrazine and TCO, has particularly appealing characteristics for in vivo pretargeting applications. Simply put, the thrust of pretargeted imaging is to harness the exquisite tumor-targeting properties...